(−)-Epicatechin treatment resulted in a clear trend toward reduced levels of β-CTF fragments likely representing lower levels of C99 (b-CTF), p-β′-CTF (C89) and/or β′-CTF ( Fig. 4 C), and consistent with reduced β-secretase processing. 3.7.
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Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.
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