We also found that irradiation decreased the number of BrdU+/NeuN+ mature neurons by 97% ( P < 0.01), and minocycline intervention slightly increased that number (4.7 ± 0.3 for the RN group vs 6.7 ± 0.7 for the RM group), but did not reach statistical significance ( P = 0.055) (Figure 3 B, C).
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Minocycline ameliorates cognitive impairment induced by whole-brain irradiation: an animal study.
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