Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug TH-302 in pancreatic cancer.

PLoS One · 2014 · PMC4273999 · PMID 25532146

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moderately significantno p-value reported

Results indicated that hydralazine improved TH-302 efficacy, albeit the effect size was small and was only moderately significant in tumors (MIA PaCa-2) that exhibit intermediate sensitivity to TH-302 as a monotherapy.

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