Barely Significant
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Control of membrane gaps by synaptotagmin-Ca2+ measured with a novel membrane distance ruler.

Nat Commun · 2014 · PMC4275583 · PMID 25500905

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quite significantno p-value reported
However, considering the above-mentioned dimensions of the SNAREs, such a change is quite significant and allows for efficient triggering at the millisecond timescale.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.