As for tomographic outcome, the minor allele homozygotes for ARMS2 rs10490924 and HTRA1 rs1100638 (GG genotype for both) were associated with a larger CSMT reduction at month 12 than other genotypes, with borderline significance after Bonferroni correction (118.6 ± 132.7 μm versus 62.7 ± 89.7 μm, corrected p = 0.0656 for rs10490924; 115.7 ± 131.7 μm versus 63.6 ± 89.8 μm, corrected p = 0.0528 for rs11200638).
Nominally significant associations were found usually under the recessive model, and the associations between all candidate polymorphisms and visual and tomographic outcome variables and the number of injections as determined by the recessive and additive models are listed in Appendix 2, Appendix 3, and Appendix 4, respectively.
Regarding tomographic outcome variables, polymorphisms at the 10q26 locus showed an association with mean CSMT change at month 12, which was marginally significant after correction.