MiR-29a reduces TIMP-1 production by dermal fibroblasts via targeting TGF-β activated kinase 1 binding protein 1, implications for systemic sclerosis.

Interestingly, HC dermal fibroblasts cultured on collagen gels secreted higher level of MMP-1 following miR-29a transfection compared to cont-miR, although the difference did not reach statistical significance ( Fig. 2D ).

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