A pharmacokinetic and pharmacodynamic investigation of Modufolin® compared to Isovorin® after single dose intravenous administration to patients with colon cancer: a randomized study.

Cancer Chemother Pharmacol · 2015 · PMC4281361 · PMID 25342290

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did not reach statistical significanceno p-value reported

A difference was also seen in tumor tissue at 60 mg/m 2 but it did not reach statistical significance, possibly due to low number of patients in the low dosage arms (Table 2 ).

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