showed a trendP = 0.08
The electrophysiological and clinical CR effects, observed in all six patients (reduction of LFP beta activity by 48% and of UPDRS motor scores by 58% compared with baseline), were cumulative; that is, after the third daily dose of CR neuromodulation (in the evening of day 3) UPDRS motor scores showed a significant improvement ( P = 0.03), and beta activity showed a trend toward a significant reduction ( P = 0.08) compared with the evening of the first day.