Barely Significant
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Coordinated reset neuromodulation for Parkinson's disease: proof-of-concept study.

Mov Disord · 2014 · PMC4282372 · PMID 24976001

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showed a trendP = 0.08so close (0.05 < p ≤ 0.1)
The electrophysiological and clinical CR effects, observed in all six patients (reduction of LFP beta activity by 48% and of UPDRS motor scores by 58% compared with baseline), were cumulative; that is, after the third daily dose of CR neuromodulation (in the evening of day 3) UPDRS motor scores showed a significant improvement ( P = 0.03), and beta activity showed a trend toward a significant reduction ( P = 0.08) compared with the evening of the first day.

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