The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density.

In keeping with the reduced lymphatic vessel density in adult CCR2-deficient mice, E15.5 mice displayed a trend towards reduction in vessel density but this did not reach statistical significance (Fig 7 Eii).

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This difference in vessel width was highly significant, and importantly, no difference in vessel width was noted in ACKR2-deficient mouse skins at this time point (Fig 7 Ei).

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