A tendency toward a decrease in HIF-1α mRNA level was observed in diabetic SIECs but did not reach statistical significance (control SIECs=1±0.16, diabetic SIECs=0.88±0.12).
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Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes.
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