Neuroprotective effect of masitinib in rats with postischemic stroke.

However, the differences did not reach statistical significance (Table 2 ).

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Masitinib is known as a strong inhibitor of PDGFR, but extracerebral inhibition of mast cell recruitment is probably the most important component of preserving BBB integrity and has highly significant impact on neuroinflammatory cascade and activity of microglia in the brain tissue (Skaper et al., 2012 ; Skaper et al. 2014 ).

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