Exposure to Kynurenic Acid during Adolescence Increases Sign-Tracking and Impairs Long-Term Potentiation in Adulthood.

One-way ANOVAs for each session revealed significant differences between the vehicle and L-KYN groups on day 1 [ F (1, 13) = 9.2, p < 0.01], day 2 [ F (1, 13) = 5.5, p < 0.03], and day 6 [ F (1, 13) = 5.6, p < 0.03], a marginally significant difference on day 3 [ F (1, 13) = 4.5, p = 0.05], and no significant differences between the groups on day 4 ( p > 0.1), day 5 ( p > 0.1), or day 7 ( p > 0.4).

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For L-KYN-treated rats, the post-induction response was only 150 ± 37% above baseline and did not reach statistical significance [ t (14) = 1.3, p > 0.2], indicating that LTP was not induced.

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