LC-MS metabolomics of psoriasis patients reveals disease severity-dependent increases in circulating amino acids that are ameliorated by anti-TNFα treatment.

observed a slightly significant ( p = 0.05–0.1) increase in plasma amino acids of cachectic compared to noncachectic COPD patients. 58 Moreover, a number of cachectic studies exhibited lower levels of circulating amino acids during cachexia in clinical as well as animal studies. 59 − 61 However, a downregulation of circulating branched-chain amino acids, which is thought to be a hallmark of cachexia, 62 was not observed in the current study.

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