Combination therapy of hypertension in the elderly: a subgroup analysis of the Combination of OLMesartan and a calcium channel blocker or diuretic in Japanese elderly hypertensive patients trial.

Compared with the olmesartan plus diuretic group, the incidences of primary end point and composite of hard end points were 29 to 36% lower as relative risk reduction in the olmesartan plus CCB group in the very elderly age group (HR, 0.71; 95% confidence interval, 0.51–0.99 for primary end point, and 0.64, 0.42–0.98 for composite of hard end points); however, the interaction- P values between the age groups did not reach statistical significance (interaction- P =0.15 for primary end point and interaction- P =0.12 for hard end point).

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