Neoadjuvant antiangiogenic therapy reveals contrasts in primary and metastatic tumor efficacy.

SCID mice bearing orthotopic melanoma (WM113/6-4L) cells treated with neoadjuvant sunitinib (60 mg/kg for 14 days) led to a trend of reduced tumor size and weight following surgical resection but yielded a trend of worsened post-surgical survival (Supplementary Fig S2A–C, both did not reach statistical significance).

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