Biologics in the management of ulcerative colitis - comparative safety and efficacy of TNF-α antagonists.

63 In this second meta-analysis, there was a trend toward increased efficacy of infliximab compared with adalimumab and golimumab, but this did not reach statistical significance. 64 Conclusion In summary, all three anti-TNF agents are shown to be effective in inducing and maintaining clinical response and remission in patients with UC, with fairly comparable safety profiles.

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