Prognostic impact of alternative splicing-derived hMENA isoforms in resected, node-negative, non-small-cell lung cancer.

3A-C ), while patients with high hMENA 11a expression had a significant and borderline significant advantage in DFS (p=0.03) and OS (p=0.056), respectively, and a non-significant trend towards better CSS (Fig. 3D-F ).

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4D-F ); despite an appreciable separation of the curves, OS differences did not reach statistical significance, due to the low number of events (36 deaths).

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At multivariate analysis, hybMENA remained a highly significant independent predictor of outcome (data not shown); Kaplan-Meier curves according to hybMENA are shown in Fig. 3G-I ; 3- and 5-year outcomes are summarized in Table S4 .

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