Phasic and tonic type A γ-Aminobutryic acid receptor mediated effect of Withania somnifera on mice hippocampal CA1 pyramidal Neurons.

J Ayurveda Integr Med · 2014 · PMC4296433 · PMID 25624695

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showed a trendP < 0.01actually significant

The magnitude showed a trend to be significantly different to that evoked in the presence of mWS [ Figure 5b and c ] (BIC, 21.7 ± 3.5 pA, n = 4 P < 0.01), suggesting sub-population of CA1 neurons is subject to both phasic and tonic GABA A receptor activation by mWS, probably through synaptic and extrasynaptic GABA A receptors, respectively.

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