Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.

In SKOV3 cells, the p-mTOR/mTOR ratio was decreased from 5.3 at the basal level to 2.9 when treated with ALS 5 μM ( Figure 12B ), but treatment of SKOV3 cells with ALS 0.1 and 1 μM for 24 hours reduced mTOR phosphorylation by 5.2% and 4.2%, respectively; however, the difference did not reach statistical significance.

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