Barely Significant
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Lung flute improves symptoms and health status in COPD with chronic bronchitis: A 26 week randomized controlled trial.

Clin Transl Med · 2014 · PMC4299801 · PMID 25625006

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These factors likely explain why the CCQ improvement in the Lung Flute group did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.