Involvement of peroxisome proliferator-activated receptors in cardiac and vascular remodeling in a novel minipig model of insulin resistance and atherosclerosis induced by consumption of a high-fat/cholesterol diet.

HFC-fed minipigs had significantly increased body weight, body mass, TC, HDL-C, LDL-C, FFA, FBG, insulin, and HOMA-IR index compared with Ctr minipigs ( P < 0.01, Table 2 ), and the TG level also showed a trend of increasing ( P > 0.05, Table 2 ).

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