Shiga toxin 2-induced endoplasmic reticulum stress is minimized by activated protein C but does not correlate with lethal kidney injury.

Kidney expression of the ER stress marker CHOP, which is at the intersection of ER stress and apoptosis [ 31 , 32 ], also was up-regulated significantly by Day 3 (7.69-fold compared to saline; p < 0.05) and remained high at euthanasia (3.88-fold increase) but differences did not reach statistical significance ( Figure 2 C).

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