Cyclooxygenases 1 and 2 differentially regulate blood pressure and cerebrovascular responses to acute and chronic intermittent hypoxia: implications for sleep apnea.

J Am Heart Assoc · 2014 · PMC4309085 · PMID 24815497

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showed a trendP =0.07so close (0.05 < p ≤ 0.1)

There was a trend for SBP to be increased in all conditions (placebo: P =0.09; nonselective COX inhibition: P =0.08; selective COX‐2 inhibition: P =0.08; Figure 3 B) while DBP was increased with the placebo ( P =0.03), showed a trend ( P =0.07) to be elevated within the nonselective COX inhibition condition, but was unchanged from the pre‐IH level with selective COX‐2 inhibition ( P =0.41; Figure 3 C).

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