Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway.

Sci Rep · 2015 · PMC4311245 · PMID 25634597

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a borderline significant trendno p-value reported

Among them, cortisol was significantly decreased and its metabolite hydroxycortisol also decreased after metformin administration, although this difference was a borderline significant trend ( Figure 2a and 2b ).

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