Cyclosporin a and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells.

All CA mutants showed impaired transduction efficiencies in CD4 + T cells, in which CypA is an LV promoting factor, despite similar infectivity as the wild-type (WT) vector in 293T cells ( Supplementary Table S1 ) ( Figure 6a , white bars, mutants versus WT, P < 0.0001 for all except A92E which did not reach statistical significance).

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