Profiles of white matter tract pathology in frontotemporal dementia.

Contrasts of MAPT and C9ORF72 mutations subgroups with sporadic bvFTD were examined but did not reach statistical significance.

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Substantial emerging histopathological evidence suggests that white matter pathology may be significant in bvFTD [Ahmed et al., 2011 ; Hiji et al., 2008 ; Neumann et al., 2007 ], may develop early in the disease process [Broe et al., 2004 ; Martin et al., 2001 ] and may promote subsequent upstream cortical degeneration [Drzezga et al., 2011 ; Villain et al., 2008 ].

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