An HDAC-dependent epigenetic mechanism that enhances the efficacy of the antidepressant drug fluoxetine.

Sci Rep · 2015 · PMC4313090 · PMID 25639887

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did not reach statistical significanceno p-value reported

1a , levels of acH4K12 at Bdnf promotors 2 and 3 were elevated in IMS mice, but compared to SFR controls, this enrichment did not reach statistical significance.

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did not quite reach significanceno p-value reported

While the increased enrichment of acH4K12 did not quite reach significance after fluoxetine mono-treatment and after fluoxetine TSA co-treatment, the enrichment measured after fluoxetine/MS-275 co-treatment was significant.

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