Barely Significant
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Effects of entecavir on hepatitis B virus covalently closed circular DNA in hepatitis B e antigen-positive patients with hepatitis B.

PLoS One · 2015 · PMC4315599 · PMID 25647607

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Our results showed that the magnitude of reduction in serum cccDNA was lower than that of total HBV DNA, but did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.