Recent coselection in human populations revealed by protein-protein interaction network.

The negative correlations between the coselection scores and SPL were highly significant in all four groups ( P = 7.8 x 10 − 9 , 2.9 x 10 − 9 , 2.9 x 10 − 9 , and 6.7 x 10 − 12 for YRI, EAS, CEU, and combined, respectively).

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In EAS, the proportions of selection increased from a significant underrepresentation at the very periphery of the network (BC = 0; nominal P = 0.001, FDR corrected P = 0.007) to a marginally significant overrepresentation with high BC scores of 2,001–20,000 (nominal P = 0.008, FDR corrected P = 0.025).

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A clear trend was lacking for the CEU population in the BC analysis ( fig. 2 B ).

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In brief, there was a weak trend of network position dependency in the recently selected genes.

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