Loss of hepatocyte growth factor activator inhibitor type 1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model.

However, at an earlier time point (24 h incubation), the difference was apparent ( P = 0.017) in S2-CP8_HAI-1#1, and PAR-2 KD, instead of the antagonist treatment, resulted in significant suppression of the invasion of S2-CP8/HAI-1tet#1 cells in the absence of Tet (Fig. 4 ).

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