nominally significantp < 0.05
In terms of the latter aspect, these four genes are indeed significant as all of them achieved nominally significant (p < 0.05) or marginally significant (p < 0.10) p values in our discovery and replication datasets.
In terms of the latter aspect, these four genes are indeed significant as all of them achieved nominally significant (p < 0.05) or marginally significant (p < 0.10) p values in our discovery and replication datasets.
Two genes, DAXX and PLK3, were successfully replicated across all the 3 replication cohorts, with significant (p <0.05) or marginally significant (p <0.10) p values as well as the same direction of regulation as in our discovery cohort ( Table 3 ).