BDNF-mediated induction of PAC 1 receptor expression showed a clear trend towards an increase, but statistical significance was reached only after 24h treatment ( F 3,11 = 18.6 , at 6h and 12h → p>0.05 Vs t0 , at 24h → **p<0.01 Vs t0 ) ( Fig. 5A and 5B ).
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PACAP interacts with PAC1 receptors to induce tissue plasminogen activator (tPA) expression and activity in schwann cell-like cultures.
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