Tungstate-targeting of BKαβ1 channels tunes ERK phosphorylation and cell proliferation in human vascular smooth muscle.

Similar to that seen in HEKαβ 1 cells (constitutively expressing the bovine α and β 1 subunits of the BK channel), treatment of human VSMCs with tungstate (1 mM for 10 minutes) promoted the phosphorylation of ERK1/2 up to slightly lower levels than PDGF treatment although this difference did not reach statistical significance (P > 0.05, ANOVA followed by Tukey post hoc test).

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