Association of DNA methylation with age, gender, and smoking in an Arab population.

[ 41 ], were highly significant (i.e. cg09809672 with p value 1.17 × 10 −17 , cg21801378 with p value 4.5 × 10 −16 , and cg00059225 with p value 9.47 × 10 −15 ).

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Since our p values relative to the rank test p values remained nominally significant when using a statistically less powerful but more robust test (data not shown), we can confirm that our small sample size and the deviation from normality do not alter the main findings/conclusions presented in this paper.

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