TNF- α and ICA treated cells subsequently treated with PDTC (NF- κ B inhibitor), Nicotinamide (SIRT6 inhibitor), or PDTC and Nicotinamide showed a trend of decreasing SIRT6 mRNA levels but these decreases were not significant when compared with TNF- α and ICA treatment ( Figure 6(a) ).
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Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF-kappa B pathway.
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