Population attributable risks of hypertension and diabetes for cardiovascular disease and stroke in the northern Manhattan study.

In a multinational clinical trial using indapamide (and perindopril as needed) in participants over 80 and with a sustained blood pressure greater than 160 mm Hg, there was a reduced risk of CHF and death, as well as a nearly significant effect on stroke. 30 In analysis of the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, investigators found that disparities in stroke incidence resulting from HTN between non‐Hispanic blacks and whites were significantly blunted in those ≥75. 31 Whether HTN needs to be as aggressively treated in the elderly, as suggested by recent reports of greater decline in total brain volume 32 and increased risk of falls in this population, 33 remains to be answered.

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