Longitudinal systolic blood pressure characteristics and integrity of white matter tracts in a cohort of very old black and white adults.

Associations between the 5 SBP trajectory groups and WMH or FA were significant or nearly significant for tracts in the left but not the right hemisphere ( Supplementary Table 3 ) and were stronger for WMH in the left uncinate fasciculus ( P = 0.02) and for FA in the left superior longitudinal fasciculus ( P = 0.008).Compared with the group with normal SBP and previously stable trajectories, the other 4 trajectory groups had a greater probability of having WMH greater than or equal to the median in the left uncinate fasciculus ( Table 4 ) and had greater FA in the left superior longitudinal fasciculus, independent of age, antihypertensive medication use, and stroke ( Table 4 ).

also in 3,360 other papers