An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation.

Whilst the inflammatory signature did not reach statistical significance in the ‘No Sepsis’ group, the contrasting relative enrichment of the Endotoxin Tolerance and inflammatory signatures in the 2 groups may indicate a fundamental difference in the balance of endotoxin tolerance and inflammation unique to sepsis patients ( Fig. 3 a).

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