While it failed to reach statistical significance, quantification of the intensity of staining in the dermis (excluding hair follicles) revealed a trend for an increase in the amount of MMP-1 in wild-type UV-irradiated mice, which was not observed in GzmB-KO UV-irradiated mice (Fig. 4D ).
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Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-dose ultraviolet light irradiation.
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