Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis.

There was a trend towards higher proportions of B2 cells in the peritoneum of old mice, but this did not quite reach statistical significance (Fig. 6E ; P = 0.057).

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CD45.1 + macrophages, injected into the peritoneum of old mice, showed a nonsignificant trend towards a reduction in percentage of phagocytic cells compared with those injected into young mice (Fig. 5A,B ), and a statistically significant decrease between these groups was apparent when mean fluorescence intensity (MFI) values were analysed (Fig. 5C ).

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Furthermore, analysis of mean fluorescence intensity, representing mean number of particles taken up by each macrophage, showed a striking and highly significant difference (Fig. 1C ), which highlighted the inefficiency of phagocytosis by macrophages from old mice.

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Results demonstrated a trend towards increased CXCL13 in lavages from old mice; however, this did not reach statistical significance (data not shown).

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