Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.

Nat Commun · 2015 · PMC4327416 · PMID 25651891

Europe PMC DOI

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP = 2.4×10 −14actually significant

Only one locus, IL23R , demonstrated true independence of the psoriasis SNP; the PsA-associated SNP rs12044149 remained highly significant ( P = 2.4×10 −14 ) after conditioning on the psoriasis SNP, rs9988642, and the addition of rs9988642 did not improve the model fit with LRT ( P = 0.21).

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modestly significantP = 0.006actually significant

A number of previous psoriasis GWAS have directly compared genotypes between PsC and PsA 14 , 30 ; for example, Nair et al found modestly significant frequency differences between PsC and PsA for SNPs at the HLA-C ( P = 0.006) and IL12B ( P = 0.01) loci 31 .

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did not reach statistical significanceP = 0.07so close (0.05 < p ≤ 0.1)

Validation of this SNP in an independent cohort of patients with PsA did not reach statistical significance ( P = 0.07).

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