Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans.

As a trend, the fractional reduction was larger in SL/SL than SL/WT KI mice, but the difference did not reach statistical significance, possibly because even in SL/SL pyramidal cells only 30% of mEPSCs were Aga-sensitive.

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