Embryonic expression of the common progeroid lamin A splice mutation arrests postnatal skin development.

Aging Cell · 2014 · PMC4331787 · PMID 24305605

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2 ), RNA expression analyses by quantitative RT–PCR showed a highly significant upregulation of inflammatory genes ( S100A8 , S100A9 , IL1F5, and Sprr2d ) in skin from PD5 progeroid animals (Fig. 5 ).

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The EGR1 gene, also associated with NF-kB, showed a trend toward activated expression (Fig. 5 ).

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