Hepatocytes maintain greater fluorescent bile acid accumulation and greater sensitivity to drug-induced cell death in three-dimensional matrix culture.

6 ), indicating that the treatments induced cell death as compared to control, although cell death response was diminished under these live cell culturing conditions and APAP treatment did not reach statistical significance ( P = 0.22, 0.002, 0.004 for APAP, GCDCA, TLCA versus control).

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