Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease.

As compared to Hydralazine-treated mice, fibrosis and plasma creatinine levels were lower in 5′-Azacytidine-treated mice, albeit differences between the groups did not reach statistical significance (Supplementary Figs. 1A–C and 2A–D). 3.2 Reno-Protective Effect of Hydralazine and Rasal1 Promoter CpG Island De-methylation We next aimed to elucidate if ameliorated fibrosis observed upon Hydralazine treatment was due to its de-methylating efficacy.

also in 111,027 other papers