Nonexocytotic serotonin release tonically suppresses serotonergic neuron activity.

J Gen Physiol · 2015 · PMC4338157 · PMID 25712017

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0.1000

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a clear trendP = 0.10so close (0.05 < p ≤ 0.1)

Under conditions where vesicular 5-HT accumulation was inhibited by Tbz, citalopram was similarly effective (EC 50 = 94.5 nM; 46.0–194.3 nM; 95% C.I.; log IC 50 not different from Ctrl, P = 0.58, F = 0.32, extra sum-of-squares F test), although a clear trend toward weaker maximal effect was observed (fit bottom = 26.7%; 9.7–43.6%; 95% C.I.; not different from Crtl, P = 0.10, F = 2.71, extra sum-of-squares F test).

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