Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice.

The action of Alda‐1 in apoE −/− mice was not associated with its influence on inflammatory processes related to progression of atherogenesis, because Alda‐1 neither changed the macrophage content in the plaques nor influenced levels of atherosclerosis‐related plasma markers of inflammation (slight decrease in levels of proinflammatory cytokines, such as IL‐12 and IL‐6, did not reach statistical significance).

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