Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle.

As can be seen in Fig 2G , muscle mitochondria from mice from the early group had a strong trend for an increase in free radical leak under both state 2 and 3 conditions ( Fig 2G : G + M, G + M + ADP + Succ).

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