Pulmonary hypertension: types and treatments.

Curr Cardiol Rev · 2015 · PMC4347212 · PMID 24251459

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a strong trendno p-value reported

Prostacyclin has been shown to improve cardiac index and decrease PVR in advanced heart failure, but create a strong trend toward increased mortality [ 49 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.