Of note, mtMSI was observed in LTAs with higher mtCN (60.0% versus 28.2%), although this did not reach statistical significance (p = 0.059). nMSI was found in 9.0% (7/78) of TAs and 11.8% (4/34) of SPs, respectively.
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Genetic characteristics of mitochondrial DNA was associated with colorectal carcinogenesis and its prognosis.
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Additionally, other studies suggested that only nMSI and KRAS and BRAF mutations may be significant markers for prognosis in CRCs [ 19 , 20 , 47 ].